美国博士后-布罗德研究所-遗传变异如何影响基因表达

发布时间：2020/8/6 15:25:59

浏览次数：次

如有招聘信息发布(博士/博后/访学)可联系

邮箱：cxw@med.tj.cn

微信：shelver888

公众号链接：https://mp.weixin.qq.com/s?__biz=MzU5NTk2OTE2Mw==&mid=2247485615&idx=1&sn=e7949e16bf6a36f3d6a201e8af489f0a&chksm=fe689d4bc91f145db077a79518c173708fdf9c76df16efa4227fca62a9e58429907ee841b9e7&token=1084612265&lang=zh_CN#rd

院所：布罗德研究所 The Eli and Edythe L. Broad Institute of MIT and Harvard

部门：Laboratory of Eric Lander

教授：Eric Lander

申请网址：https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_institute/job/Cambridge-MA/Postdoctoral-Fellow_2143?sid=68 

截止日期：未定

介绍

这个职位是一个极难得的机会，可以加入麻省理工学院和哈佛大学布罗德研究所埃里克·兰德实验室学习基因组生物学，埃里克·兰德既是研究所的创始人也是所长。我们对人类基因组如何在健康和疾病中起作用的各个方面都感兴趣，包括非编码DNA元素在基因表达动态调节中的作用。我们正在招收一位上进心强的人员，在系统生物学和遗传学方面具有丰富经验，掌握了强大的生物学定量方法，可推动非编码基因组的深入研究。具有基因组学和/或增强子生物学经验者优先。成功的候选人会与拥有实验科学家和计算科学家的团队合作，应用这些高通量工具来表征全基因组调控DNA元件的功能及其在健康和疾病中的作用。

关于职位：

我们正在寻找一个极富创造力和积极进取的个人，与我们一起研究遗传变异如何影响基因表达。成功的候选人将与内部和外部团队合作解决具有挑战性的生物学问题。这项工作将是多学科的，结合了分子生物学，遗传学和基因组学，并将与实验学家、计算生物学家和数学家建立密切的合作。

主要职责包括：

应用并创建计算框架，利用单细胞数据来揭示和学习各种细胞类型和细胞组织中的细胞程序。

开发单细胞数据管道用以设计和执行功能遗传筛选的实验，从而生成可调节多种细胞类型基因表达的非编码元件的全面图。

管理研究团队并协调复杂的合作项目，比如功能基因组学与分子遗传学，癌症生物学和免疫疾病的项目

利用自身的科学创造力，与他人合作，并独立思考来扩展技术能力，发现新的研究机会

要求

合格的候选人应具备：

遗传学，系统生物学，计算生物学，分子生物学或相关领域的博士学位，会使用计算方法来增加生物学知识和应用生物学

具有下一代测序工作流程和分析的经验

出色的出版记录和出色的沟通能力

出色的组织和时间管理技能

必须能够处理各种任务并适应极度多变的环境

申请

申请：https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_institute/job/Cambridge-MA/Postdoctoral-Fellow_2143?sid=68

Job description

This position is a unique opportunity to join the laboratory of Eric Lander, Founder and Director of the Broad Institute of MIT and Harvard, to study genome biology. We are interested in all aspects of how the human genome works in health and disease, including the role of non-coding DNA elements in the dynamic regulation of gene expression. We are looking for a highly motivated individual with significant experience in systems biology and genetics as well as strong quantitative approaches in biology to facilitate the study of the non-coding genome. Experience in genomics and/or enhancer biology is preferred. A successful candidate will work with a team of experimental and computational scientists to apply these high-throughput tools to characterize the function of regulatory DNA elements genome-wide and their role in health and disease. The Lander Laboratory is a dynamic, interdisciplinary workplace that will provide unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of resulting scientific contributions.

About the Position:

We are looking for an exceptionally creative and self-motivated individual to join us in studying how genetic variants affect gene expression. A successful candidate will collaborate with internal and external groups to solve challenging biological problems. The work will be multi-disciplinary, combining molecular biology, genetics and genomics and will work closely with experimentalists,

computational biologists and mathematicians.

Key responsibilities include:

Apply and create computational frameworks for uncovering and understanding cellular programs in various cell types and tissues using single cell data.

Develop single cell data pipelines to design and execute function genetic screens to generate a comprehensive map of noncoding elements that regulate gene expression in multiple cell types.

Manage a team of research associates and coordinated complex collaborative projects at the intersection of functional genomics with molecular genetics, cancer biology, and immune diseases

Use demonstrated scientific creativity, collaboration with others, and independent thought to expand technical capabilities and identify new research opportunities

我们为您提供更专业的出国方案—免费获取定制出国方案